Journal article
Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens
S Durschmid, T Zaehle, H Hinrichs, HJ Heinze, J Voges, MI Garrido, RJ Dolan, RT Knight
Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2016
Abstract
Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was funded by NINDS grant 2R37NS21135, the Nielsen Corporation, Forschungscampus Stimulate, Land Sachsen-Anhalt FKZ I60, Land Sachsen-Anhalt Exzellenzforderung, the Wellcome Trust 091593/Z/10/Z, DFG-SFB 779/TP A2 (T.Z. and H.-J.H.), TP A3 (H.-J.H.) and TP A11 (J.V. and H.-J.H.), DFG He 1531/11-1 (J.V. and H.-J.H.), Federal Ministry of Education and Research (grant no. 03FO16102A) (J.V.), Australian Research Council Discovery Early Career Researcher Award (DE130101393) (M.I.G.), the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007) (M.I.G.). This work was supported by the Wellcome Trust (R.J.D Senior Investigator Award 098362/Z/12/Z). The Wellcome Trust Centre for Neuroimaging was supported by core funding from the Wellcome Trust 091593/Z/10/Z.